The cultural mélange that characterizes Spice on Hollywood's menu draws inspiration from across the globe, incorporating familiar American, Mexican, and Italian recipes. Regardless of the dish's origin, the chefs demonstrate a commitment to homestyle flavors by making tomato sauces and pico de gallo salsa in-house. Pizzas can arrive decked with any of 14 available toppings—including barbecued chicken, feta cheese, and basil—and savory mushrooms accompany servings of flame-grilled rib-eye steak. These varied cuisines also influence the eatery's menu of breakfast staples, which features huevos rancheros and black beans alongside belgian waffles with fresh strawberries and powdered sugar.
The intimately sized dining area creates a cozy, café-like ambiance. Chalkboards with daily specials line a wall behind the front counter, pendant lamps gently illuminate dark wooden tables, and floor-to-ceiling windows flood the room with natural light for diners who prefer to cook their own meals photosynthetically.