Since opening My Sister’s Closet in 1982, Joanne Nusbaum has trained her eye to hone in on high-end apparel for women of all ages and sizes. She lines the shelves with a vast, constantly updated collection in her sunny, 3,600-square-foot storefront, which also spills over with home decor such as lamps and glassware. Before accepting consignment pieces, she turns her expert eye on every fold of fabric, scouring the garments for loose stitches, wonky buttons, or nests of live squirrels, and scrutinizes tags to ensure brand authenticity. Though she carries mostly new, designer apparel, hidden gems such as vintage and antique accessories peek out from the racks. Additionally, Ms. Nusbaum sends out feelers for new consignment pieces from customers or skeletons tired of sharing closet space with top-hat collections.