Duffy’s Irish Pub specializes in making award-winning chicken wings, voted the city's best in 2017 by readers of Washington City Paper as well as the "Best Chicken Wings in the U.S." by Food and Wine Magazine. The restaurant offers a variety of seven different wing types, from buffalo style to the award winning Chesapeake Bay wings, using their signature wing sauce which has been featured in the Washington Post. Additionally, this spot provides customers with a range of pub, grass-fed, and black-bean burger patty options, such as the Monster Burger that earns its name by piling bacon, grilled onions, and a half-pound burger between two grilled cheese sandwiches. It also crafts unique Bloody Mary cocktails that include Duffy's special wing sauce.

Along with the menu of daily grub, Duffy's supplies discounted drinks and discount appetizers for weekday happy hours and hosts brain-teasing pub trivia challenges on Tuesday nights. It hangs 15 flat-screen TVs throughout the bar, usually tuned to the latest games such as the Texas Exes Football and Georgetown Basketball, and serves as an official watch bar of DC United. In addition to front-of-the-house entertainment, Duffy's accommodates private parties in a back room equipped with more flat-screens, darts, and a phone app-controlled jukebox.