Though built in 1893 to manufacture textiles, the Columbia Mills’ storied stone halls now weave tapestries of knowledge with exhibits on everything from lasers and space travel to South Carolina's role in the Civil War. Boasting accolades by Columbia Metropolitan magazine and the Smithsonian, South Carolina State Museum devotes each of its four floors and part of its fourth dimension to art, cultural history, natural history, and science and technology represented by more than 70,000 artifacts.

Through a series of permanent exhibits, curators lead visitors on a cultural and geological voyage. Guests stroll through years of traditional and contemporary art by state artists, marvel at a 43-foot white shark display and full dinosaur skeletons, or cast imaginations back in exhibits on turn-of-the-century transportation, laser technology, and aviation. The museum also excavates the surrounding landscape to present 14,000 years of local culture in Native American tools and colonial-era lifestyle items.

Five galleries also house changing exhibits featuring assemblages of artifacts from Civil War–era Charleston or 300 years of American-made telescopes, each carefully monitored to ensure they contain just the right amount of science. While museum staffers frequently rotate their exhibits, they also host traveling displays and send others on the road through the Traveling Exhibits Program. Various education displays such as interactive children's labs, living-history reenactments, and lectures from visiting scholars further enrich all-ages visitors.