The firefighters of Engine Company #45 Firehouse extinguished their last blaze in 1962 after 56 years of fearless public service. Although the team dissipated, the elegant, 1906 firehouse—with Renaissance Revival details and three doors wide enough to accommodate horse-drawn fire engines—remained, languishing as a city storehouse until 1980, when the Fire Museum of Greater Cincinnati moved in. The building was recognized on the National Register of Historic Places and filled with special exhibits. It was also filled with antique firefighting gear that is in excellent condition in spite of years of smoke inhalation.

The collection reveals early 19th-century firefighting tactics with an alarm drum that once warned of fire from the roof of a carpenter shop and was later used to provide rhythm during disco infernos. In the Safe House exhibit, families diagram their homes and create personalized emergency plans while learning tips about fire prevention.