Ten Thousand Vines Buffalo, Hamburg

On the corner of Buffalo and Main Street, Ten Thousand Vines inhabits a quaint brick building outfitted with a microwinery and tasting room. As a winery free from ties to a particular vineyard, Ten Thousand Vines can source its grapes from all around the world—even Antarctica—a practice that inspired the winery's name. The vintners prepare each variety in small batches and carry more than 40 wines in their retail store.

At a tasting bar, open Tuesday–Saturday, curious sippers perch around a quarter-circle bar to sniff and swirl offerings such as Nooks & Crannies, a cranberry-chianti blend, or the delicate Delaware, made from New York grapes. The shop's resident enophiles share their passion with guests in 90-minute winemaking classes, bolstered by a wealth of wine kits and raw-grape juices.