The American Red Cross of South Carolina is part of an international, politically neutral movement that has delivered humanitarian care since 1863. It provides relief to survivors of national and manmade disasters in the forms of shelter, food, clothing, medication, and counseling. The organization also works to prevent future emergencies, and prepares community members to respond to them when they occur.

In South Carolina, the Red Cross collects blood donations, provides resources for the armed forces, and hosts health and safety training programs for citizens, including lifeguard and CPR training. Its volunteers also provide physical and emotional aid to survivors of disasters such as fires.